- aut = "Vassili Soumelis"
- Artículo:
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
- Autor:
Cristiana Guiducci
Mei Gong
Zhaohui Xu
Michelle Gill
Damien Chaussabel
Thea Meeker
Jean H. Chan
Tracey Wright
Marilynn Punaro
Silvia Bolland
Vassili Soumelis
Jacques Banchereau
Robert L. Coffman
Virginia Pascual & Franck J. Barrat
- Resumen:
Glucocorticoids are widely used to treat patients with autoimmune diseases such as systemic lupus erythematosus (SLE), but many treatment regimens cannot maintain disease control in SLE patients. Here it is shown that the stimulation of plasmacytoid dendritic cells through toll-like receptors TLR7 and TLR9 can account for the reduced activity of glucocorticoids to inhibit the type I interferon pathway in SLE patients. Thus inhibitors of TLR7 and TLR9 signalling might prove to be effective corticosteroid-sparing drugs.
- Página:
937
- Publicación:
Nature
- Volúmen:
465
- Número:
7300
- Periodo:
17 Junio 2010
- ISSN:
00280836
- SrcID:
00280836-2010-06-17.txt
- Documento número 307826
- Actualizado el martes, 23 de mayo de 2017 03:58:18 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:18 p. m.
- Enlace directo
- Artículo:
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
- Autor:
Cristiana Guiducci
Mei Gong
Zhaohui Xu
Michelle Gill
Damien Chaussabel
Thea Meeker
Jean H. Chan
Tracey Wright
Marilynn Punaro
Silvia Bolland
Vassili Soumelis
Jacques Banchereau
Robert L. Coffman
Virginia Pascual & Franck J. Barrat
- Resumen:
Glucocorticoids are widely used to treat patients with autoimmune diseases such as systemic lupus erythematosus (SLE), but many treatment regimens cannot maintain disease control in SLE patients. Here it is shown that the stimulation of plasmacytoid dendritic cells through toll-like receptors TLR7 and TLR9 can account for the reduced activity of glucocorticoids to inhibit the type I interferon pathway in SLE patients. Thus inhibitors of TLR7 and TLR9 signalling might prove to be effective corticosteroid-sparing drugs.
- Página:
937
- Publicación:
Nature
- Volúmen:
465
- Número:
7300
- Periodo:
17 Junio 2010
- ISSN:
00280836
- SrcID:
00280836-2010-06-17.txt
- Documento número 1206695
- Actualizado el martes, 10 de julio de 2018 11:33:59 a. m.
- Creado el martes, 10 de julio de 2018 11:33:59 a. m.
- Enlace directo
- 1-2