1. aut = "Vassili Soumelis"
Se encontraron 2 resultados.
Artículo:

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

Autor:

Cristiana Guiducci

Mei Gong

Zhaohui Xu

Michelle Gill

Damien Chaussabel

Thea Meeker

Jean H. Chan

Tracey Wright

Marilynn Punaro

Silvia Bolland

Vassili Soumelis

Jacques Banchereau

Robert L. Coffman

Virginia Pascual & Franck J. Barrat

Resumen:

Glucocorticoids are widely used to treat patients with autoimmune diseases such as systemic lupus erythematosus (SLE), but many treatment regimens cannot maintain disease control in SLE patients. Here it is shown that the stimulation of plasmacytoid dendritic cells through toll-like receptors TLR7 and TLR9 can account for the reduced activity of glucocorticoids to inhibit the type I interferon pathway in SLE patients. Thus inhibitors of TLR7 and TLR9 signalling might prove to be effective corticosteroid-sparing drugs.

Página:

937

Publicación:

Nature

Volúmen:

465

Número:

7300

Periodo:

17 Junio 2010

ISSN:

00280836

SrcID:

00280836-2010-06-17.txt

  • Documento número 307826
  • Actualizado el martes, 23 de mayo de 2017 03:58:18 p. m.
  • Creado el martes, 23 de mayo de 2017 03:58:18 p. m.
  • Enlace directo
Artículo:

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

Autor:

Cristiana Guiducci

Mei Gong

Zhaohui Xu

Michelle Gill

Damien Chaussabel

Thea Meeker

Jean H. Chan

Tracey Wright

Marilynn Punaro

Silvia Bolland

Vassili Soumelis

Jacques Banchereau

Robert L. Coffman

Virginia Pascual & Franck J. Barrat

Resumen:

Glucocorticoids are widely used to treat patients with autoimmune diseases such as systemic lupus erythematosus (SLE), but many treatment regimens cannot maintain disease control in SLE patients. Here it is shown that the stimulation of plasmacytoid dendritic cells through toll-like receptors TLR7 and TLR9 can account for the reduced activity of glucocorticoids to inhibit the type I interferon pathway in SLE patients. Thus inhibitors of TLR7 and TLR9 signalling might prove to be effective corticosteroid-sparing drugs.

Página:

937

Publicación:

Nature

Volúmen:

465

Número:

7300

Periodo:

17 Junio 2010

ISSN:

00280836

SrcID:

00280836-2010-06-17.txt

  • Documento número 1206695
  • Actualizado el martes, 10 de julio de 2018 11:33:59 a. m.
  • Creado el martes, 10 de julio de 2018 11:33:59 a. m.
  • Enlace directo