Artículo:

Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome

Autor:

Louise E. Reynolds

Alan R. Watson

Marianne Baker

Tania A. Jones

Gabriela D’Amico

Stephen D. Robinson

Carine Joffre

Sarah Garrido-Urbani

Juan Carlos Rodriguez-Manzaneque

Estefanía Martino-Echarri

Michel Aurrand-Lions

Denise Sheer

Franca Dagna-Bricarelli

Dean Nizetic

Christopher J. McCabe

Andrew S. Turnell

Stephanie Kermorgant

Beat A. Imhof

Ralf Adams

Elizabeth M. C. Fisher

Victor L. J. Tybulewicz

Ian R. Hart

Kairbaan M. Hodivala-Dilke

Resumen:

Down's syndrome is caused by trisomy of chromosome 21, and it is known that the growth of certain tumours is reduced in this genetic disorder. Using a mouse model of Down's syndrome, several individual genes on chromosome 21 are now being proposed to mediate the effect on tumour growth and angiogenesis.

Página:

813

Publicación:

Nature

Volúmen:

465

Número:

7299

Periodo:

10 Junio 2010

ISSN:

00280836

SrcID:

00280836-2010-06-10.txt