Quantum mechanics provides an accurate description of a wide variety of physical systems but it is very challenging to prove that it also applies to macroscopic (classical) mechanical systems. This is because it has been impossible to cool a mechanical mode to its quantum ground state, in which all classical noise is eliminated. Recently, various mechanical devices have been cooled to a near-ground state, but this paper demonstrates the milestone result of a piezoelectric resonator with a mechanical mode cooled to its quantum ground state

Copy number variants (CNVs) account for a major proportion of human genetic diversity and may contribute to genetic susceptibility to disease. Here, a large, genome-wide study of association between common CNVs and eight common human diseases is presented. The study provides a wealth of technical insights that will inform future study design and analysis. The results also indicate that common CNVs that can be 'typed' on existing platforms are unlikely to contribute much to the genetic basis of common diseases