High-throughput microscopy combined with gene silencing by RNA interference is a powerful method for studying gene function. Here, a genome-wide method is presented for phenotypic screening of each of the ~21,000 human protein-coding genes, using two-day imaging of dividing cells with fluorescently labelled chromosomes. The method enabled the identification of hundreds of genes involved in biological functions such as cell division, migration and survival

Massive galaxies in the early Universe have been shown to be forming stars at high rates. Probing the properties of individual star-forming regions is beyond the resolution and sensitivity of existing telescopes. Here, however, observations are reported of the galaxy SMMJ2135–0102 at redshift z=2.3259, which has been gravitationally magnified by a factor of 32 by a galaxy cluster lens in the foreground. The physics underlying star formation here is similar to that in local galaxies, but the energetics are very different

Our current concepts of abrupt climate change are influenced by palaeoclimate evidence for events such as the Younger Dryas cold interval, in which massive climate changes occurred essentially instantaneously. It is thought that an injection of fresh water from the retreating Laurentide Ice Sheet altered the Atlantic meridional overturning circulation and triggered the Younger Dryas, but convincing geological evidence has been elusive. Here, a major flood event that is chronologically consistent with the Younger Dryas has been identified—through the MacKenzie River into the Arctic Ocean