Catálogo de revistas impresas de la biblioteca

Se encontraron 135 resultados.

Artículo:: Cancer: Drug-tolerant insurgents
Autor:: Paul Workman
Resumen:: Some cancer cells that become tolerant to a drug remain resistant even after its withdrawal, yet these cells eventually become sensitive to the drug again. The underlying molecular mechanism is unusual
Página:: 844
Publicación:: Nature
Volúmen:: 464
Número:: 7290
Periodo:: 08 Abril 2010
ISSN:: 00280836
SrcID:: 00280836-2010-04-08.txt

Artículo:: Quantum spin liquid emerging in two-dimensional correlated Dirac fermions
Autor:: Z. Y. Meng
Resumen:: A quantum spin liquid is a hypothetical system of spins (such as those carried by electrons), the orientations of which continue to fluctuate even at absolute zero. Theoretical and experimental evidence for the existence of such states at the microscopic level is elusive, but these authors have modelled correlated electrons arranged on a honeycomb lattice (such as in graphene), and identified the conditions under which a microscopic quantum spin liquid would be realized in two dimensions
Página:: 847
Publicación:: Nature
Volúmen:: 464
Número:: 7290
Periodo:: 08 Abril 2010
ISSN:: 00280836
SrcID:: 00280836-2010-04-08.txt

Artículo:: Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
Autor:: Marc H. G. P. Raaijmakers
Resumen:: A new mouse model is developed in which haematopoietic malignancies are caused by genetic changes in the microenvironment of blood cells. Deletion in bone progenitor cells of Dicer1, a gene involved in microRNA processing, leads to a myelodysplastic syndrome-like phenotype which can progress to leukaemia. Deregulation of Sbds, which is mutated in human Schwachman–Bodian–Diamond syndrome, may be involved in this process
Página:: 852
Publicación:: Nature
Volúmen:: 464
Número:: 7290
Periodo:: 08 Abril 2010
ISSN:: 00280836
SrcID:: 00280836-2010-04-08.txt

Artículo:: Zscan4 regulates telomere elongation and genomic stability in ES cells
Autor:: Michal Zalzman
Resumen:: Zscan4 is shown to be involved in maintaining telomeres in embryonic stem (ES) cells. Only 5% of ES cells express Zscan4 at a given time, but nearly all ES cells activate Zscan4 at least once within nine passages. The transient Zscan4-positive state is associated with rapid telomere extension by telomere recombination and upregulation of meiosis–specific homologous recombination genes. Knocking down Zscan4 shortens telomeres, increases karyotype abnormalities and spontaneous sister chromatid exchange, and slows down cell proliferation until reaching crisis by eight passages
Página:: 858
Publicación:: Nature
Volúmen:: 464
Número:: 7290
Periodo:: 08 Abril 2010
ISSN:: 00280836
SrcID:: 00280836-2010-04-08.txt

Artículo:: Molecular mechanism of multivesicular body biogenesis by ESCRT complexes
Autor:: Thomas Wollert
Resumen:: Here, multivesicular body (MVB) biogenesis is reconstituted using giant unilamellar vesicles and all of the ESCRT complexes. ESCRT-0 is required for clustering of cargo proteins, whereas ESCRT-I and -II in combination deform the membrane into buds, in which cargo is confined. ESCRT-III subunits localize to the bud neck and are required for scission of the membrane to form intraluminal vesicles. These results explain how ESCRT complexes sequester cargo proteins into MVBs
Página:: 864
Publicación:: Nature
Volúmen:: 464
Número:: 7290
Periodo:: 08 Abril 2010
ISSN:: 00280836
SrcID:: 00280836-2010-04-08.txt

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