Here, artificial proteins are described that mimic the molecular architecture of titin — a protein that helps to govern the passive elastic properties of muscle. The new artificial proteins combine structured and unstructured domains, and can be photochemically crosslinked into a solid biomaterial that is resilient at low strains and extensible and tough at high strains. This provides an example of tailoring the macroscopic properties of a material through engineering at the single-molecule level

Slip on a subduction megathrust can occur during an earthquake or aseismically. The size, location and frequency of earthquakes that a megathrust can generate depend on where and when aseismic creep is taking place, and what fraction of the long-term slip it accounts for. Here this issue is addressed by looking at the central Peru megathrust, and specifically at the Pisco earthquake of 2007. The findings show that aseismic creep accounts for 50–70% of the slip budget on the seismogenic portion of the megathrust

Notch and Delta are transmembrane proteins that allow neighbouring cells to communicate during development. Here, quantitative time-lapse microscopy has been used to show that the response of Notch to Delta on a neighbouring cell is graded, whereas its response to Delta on the same cell is sharp and occurs at a fixed threshold. A mathematical model explores how this new design principle enhances the sharpness of developmental boundaries set by classical lateral inhibition