Catálogo de revistas impresas de la biblioteca

Se encontraron 60 resultados.

Artículo:: A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
Autor:: Thorlakur Jonsson, et al.
Resumen:: A coding mutation in APP, the gene that encodes the amyloid-? precursor protein, is found to protect against Alzheimer’s disease and cognitive decline in the elderly without Alzheimer’s disease.
Página:: 96
Sección:: Letters
Publicación:: Nature
Volúmen:: 488
Número:: 7409
Periodo:: 2 agosto 2012
ISSN:: 00280836
SrcID:: 00280836-2012-08-02.txt

Artículo:: Dissecting the genomic complexity underlying medulloblastoma OPEN
Autor:: David T. W. Jones, et al.
Resumen:: Medulloblastoma is the most common brain tumour in children; using whole-genome sequencing of tumour samples the authors show that the clinically challenging Group 3 and 4 tumours can be tetraploid, and reveal the expression of the first medulloblastoma fusion genes identified.
Página:: 100
Sección:: Letters
Publicación:: Nature
Volúmen:: 488
Número:: 7409
Periodo:: 2 agosto 2012
ISSN:: 00280836
SrcID:: 00280836-2012-08-02.txt

Artículo:: Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
Autor:: Trevor J. Pugh, et al.
Resumen:: Medulloblastoma is the most common brain tumour in children; using exome sequencing of tumour samples the authors show that these cancers have low mutation rates and identify 12 significantly mutated genes, among them the gene encoding RNA helicase DDX3X.
Página:: 106
Sección:: Letters
Publicación:: Nature
Volúmen:: 488
Número:: 7409
Periodo:: 2 agosto 2012
ISSN:: 00280836
SrcID:: 00280836-2012-08-02.txt

Artículo:: Targeting nuclear RNA for in vivo correction of myotonic dystrophy
Autor:: Thurman M. Wheeler, et al.
Resumen:: Nuclear-retained transcripts containing expanded repeats are shown to be sensitive to antisense silencing, and in a transgenic mouse model of myotonic dystrophy type 1, systemic administration of ASOs causes a rapid knockdown of the toxic RNA in skeletal muscle, correcting some hallmark features of the disease.
Página:: 111
Sección:: Letters
Publicación:: Nature
Volúmen:: 488
Número:: 7409
Periodo:: 2 agosto 2012
ISSN:: 00280836
SrcID:: 00280836-2012-08-02.txt

Artículo:: A map of the cis-regulatory sequences in the mouse genome
Autor:: Yin Shen, et al.
Resumen:: A genomic map of nearly 300,000 potential cis-regulatory sequences determined from diverse mouse tissues and cell types reveals active promoters, enhancers and CCCTC-binding factor sites encompassing 11% of the mouse genome and significantly expands annotation of mammalian regulatory sequences.
Página:: 116
Sección:: Letters
Publicación:: Nature
Volúmen:: 488
Número:: 7409
Periodo:: 2 agosto 2012
ISSN:: 00280836
SrcID:: 00280836-2012-08-02.txt

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