Catálogo de revistas impresas de la biblioteca

Se encontraron 62 resultados.

Artículo:: IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
Autor:: Masato Sasaki, Christiane B. Knobbe, Joshua C. Munger, Evan F. Lind, Dirk Brenner+ et al.
Resumen:: Mutations in isocitrate dehydrogenases IDH1 and IDH2 are common in human gliomas and acute myeloid leukaemias; here, mice that carry the IDH1(R132H) mutation are described, in a new model that should help in investigating the links between mutant IDH1 and leukaemia.
Página:: 656
Sección:: Letters
Publicación:: Nature
Volúmen:: 488
Número:: 7413
Periodo:: 30 agosto 2012
ISSN:: 00280836
SrcID:: 00280836-2012-08-30.txt

Artículo:: Recurrent R-spondin fusions in colon cancer
Autor:: Somasekar Seshagiri, Eric W. Stawiski, Steffen Durinck, Zora Modrusan, Elaine E. Storm+ et al.
Resumen:: Exomes, transcriptomes and copy-number alterations in a sample of more than 70 primary human colonic tumours were analysed in an attempt to characterize the genomic landscape; in addition to finding alterations in genes associated with commonly mutated signalling pathways, recurrent gene fusions involving R-spondin family members were also found to occur in approximately 10% of colonic tumours, revealing a potential new therapeutic target.
Página:: 660
Sección:: Letters
Publicación:: Nature
Volúmen:: 488
Número:: 7413
Periodo:: 30 agosto 2012
ISSN:: 00280836
SrcID:: 00280836-2012-08-30.txt

Artículo:: Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
Autor:: Bon-Kyoung Koo, Maureen Spit, Ingrid Jordens, Teck Y. Low, Daniel E. Stange+ et al.
Resumen:: In vivo and in vitro studies show that the stem-cell E3 ubiquitin ligases RNF43 and ZNRF3 act as tumour suppressors in colorectal cancer models, and are involved in the negative regulation of the cancer-associated Wnt signalling pathway through limiting the cell-surface expression of Wnt receptors.
Página:: 665
Sección:: Letters
Publicación:: Nature
Volúmen:: 488
Número:: 7413
Periodo:: 30 agosto 2012
ISSN:: 00280836
SrcID:: 00280836-2012-08-30.txt

Artículo:: Novel role of PKR in inflammasome activation and HMGB1 release
Autor:: Ben Lu, Takahisa Nakamura, Karen Inouye, Jianhua Li, Yiting Tang+ et al.
Resumen:: Double-stranded RNA-dependent protein kinase (PKR) is shown to be a key regulator of the inflammasome; PKR is central for caspase-1 activation and the release of interleukin (IL)-1?, IL-18 and high-mobility group box 1 (HMGB1) in response to a diverse range of stimuli.
Página:: 670
Sección:: Letters
Publicación:: Nature
Volúmen:: 488
Número:: 7413
Periodo:: 30 agosto 2012
ISSN:: 00280836
SrcID:: 00280836-2012-08-30.txt

Artículo:: T cells become licensed in the lung to enter the central nervous system
Autor:: Francesca Odoardi, Christopher Sie, Kristina Streyl, Vijay K. Ulaganathan, Christian Schläger+ et al.
Resumen:: A Lewis rat model of experimental autoimmune encephalomyelitis is used to show that on their way to the CNS, encephalitogenic T-cell blasts are temporarily resident in the lung, where they reprogram their gene-expression profile and functional properties to enable them to transgress the blood–brain barrier into the CNS.
Página:: 675
Sección:: Letters
Publicación:: Nature
Volúmen:: 488
Número:: 7413
Periodo:: 30 agosto 2012
ISSN:: 00280836
SrcID:: 00280836-2012-08-30.txt

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