- importsource = "00280836-2010-05-06.txt"
- Artículo:
The molecular basis for water taste in Drosophila
- Autor:
Peter Cameron
- Resumen:
Animals must detect water in their environment to stay alive, but the molecular basis for water detection has been unclear. Here the essential mediators of water-sensing and drinking in fruitflies have been identified: an ion channel of the degenerin/epithelial sodium channel family, and the sensory neurons that make it
- Página:
91
- Publicación:
Nature
- Volúmen:
464
- Número:
7294
- Periodo:
06 Mayo 2010
- ISSN:
00280836
- SrcID:
00280836-2010-05-06.txt
- Documento número 307504
- Actualizado el martes, 23 de mayo de 2017 03:58:16 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:16 p. m.
- Enlace directo
- Artículo:
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
- Autor:
Min Gao
- Resumen:
Almost 200 million people worldwide are chronically infected with hepatitis C virus. Current treatments are poorly tolerated and not wholly effective, so new drugs are needed. Here, a potent new inhibitor of hepatitis C virus is described. This inhibitor targets the viral protein NS5A, and shows potential as part of a therapeutic regimen based on a combination of viral inhibitors
- Página:
96
- Publicación:
Nature
- Volúmen:
464
- Número:
7294
- Periodo:
06 Mayo 2010
- ISSN:
00280836
- SrcID:
00280836-2010-05-06.txt
- Documento número 307505
- Actualizado el martes, 23 de mayo de 2017 03:58:16 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:16 p. m.
- Enlace directo
- Artículo:
The scaffold protein Ste5 directly controls a switch-like mating decision in yeast
- Autor:
Mohan K. Malleshaiah
- Resumen:
Before mating, a yeast cell must detect a partner cell that is close enough and expresses sufficiently large amounts of a sex pheromone. The mating decision is an all-or-none, switch-like response to pheromone concentration. It is now shown that this decision involves the competition of one kinase and one phosphatase enzyme for multiple phosphorylation sites on a 'scaffold' protein. The results should prompt a re-evaluation of the role of related signalling molecules that have been implicated in cancer
- Página:
101
- Publicación:
Nature
- Volúmen:
464
- Número:
7294
- Periodo:
06 Mayo 2010
- ISSN:
00280836
- SrcID:
00280836-2010-05-06.txt
- Documento número 307506
- Actualizado el martes, 23 de mayo de 2017 03:58:16 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:16 p. m.
- Enlace directo
- Artículo:
An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation
- Autor:
Zhihuan Gao
- Resumen:
DNA methylation is an important epigenetic mark in many eukaryotes. In Arabidopsis plants, small interfering RNAs bound to the Argonaute 4 (AGO4) protein can direct de novo DNA methylation and consequent gene silencing. Here, a new regulator of RNA-directed DNA methylation has been discovered. This protein, RDM1, is proposed to bind to methylated DNA and to function in the AGO4 effector complex
- Página:
106
- Publicación:
Nature
- Volúmen:
464
- Número:
7294
- Periodo:
06 Mayo 2010
- ISSN:
00280836
- SrcID:
00280836-2010-05-06.txt
- Documento número 307507
- Actualizado el martes, 23 de mayo de 2017 03:58:16 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:16 p. m.
- Enlace directo
- Artículo:
X-ray crystal structure of the light-independent protochlorophyllide reductase
- Autor:
Norifumi Muraki
- Resumen:
The ability of plants to 'green' in the dark is attributed to the activity of the dark-operative protochlorophyllide oxidoreductase (DPOR). This enzyme catalyses the stereospecific reduction of the C17=C18 double bond of protochlorophyllide to form chlorophyllide a, the direct precursor of chlorophyll a. The X-ray crystal structure of the catalytic component of DPOR has now been solved. A chemical mechanism is proposed by which the reduction of the double bond may occur
- Página:
110
- Publicación:
Nature
- Volúmen:
464
- Número:
7294
- Periodo:
06 Mayo 2010
- ISSN:
00280836
- SrcID:
00280836-2010-05-06.txt
- Documento número 307508
- Actualizado el martes, 23 de mayo de 2017 03:58:16 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:16 p. m.
- Enlace directo