- importsource = "00280836-2010-07-22.txt"
- Artículo:
Co-option of the hormone-signalling module dafachronic acid–DAF-12 in nematode evolution
- Autor:
Gilberto Bento
Akira Ogawa
Ralf J. Sommer
- Resumen:
Plants or animals with identical genomes in a given species can develop into wildly differing forms, depending on environmental conditions, a phenomenon that is widespread in nature yet rarely described in genetic and molecular terms. These authors show that the formation of additional teeth-like structures in the mouth of the nematode Pristionchus pacificus in response to overcrowding is mediated by the same endocrine system that controls dauer larva formation.
- Página:
494
- Publicación:
Nature
- Volúmen:
466
- Número:
7305
- Periodo:
22 Julio 2010
- ISSN:
00280836
- SrcID:
00280836-2010-07-22.txt
- Documento número 308091
- Actualizado el martes, 23 de mayo de 2017 03:58:20 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:20 p. m.
- Enlace directo
- Artículo:
A new DAF-16 isoform regulates longevity
- Autor:
Eun-Soo Kwon
Sri Devi Narasimhan
Kelvin Yen
Heidi A. Tissenbaum
- Resumen:
The insulin/IGF-1 signalling (IIS) pathway is involved in various biological processes, including regulation of longevity. In the worm Caenorhabditis elegans, the transcription factor DAF-16a, one of two isoforms, has a major role in this pathway, regulating longevity, stress response and dauer diapause. These authors describe a new isoform, DAF-16d/f, which is also important in the regulation of lifespan. The DAF-16 isoforms functionally cooperate to fine-tune IIS-mediated processes in the context of a whole organism.
- Página:
498
- Publicación:
Nature
- Volúmen:
466
- Número:
7305
- Periodo:
22 Julio 2010
- ISSN:
00280836
- SrcID:
00280836-2010-07-22.txt
- Documento número 308092
- Actualizado el martes, 23 de mayo de 2017 03:58:20 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:20 p. m.
- Enlace directo
- Artículo:
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development
- Autor:
Hank H. Qi
Madathia Sarkissian
Gang-Qing Hu
Zhibin Wang
Arindam Bhattacharjee
D. Benjamin Gordon
Michelle Gonzales, Fei Lan
Pat P. Ongusaha
Maite Huarte
Nasser K. Yaghi
Huijun Lim
Benjamin A. Garcia
Leonardo Brizuela
Keji Zhao
Thomas M. Roberts
Yang Shi
- Resumen:
PHF8 is a JmjC domain-containing protein, the gene for which has been linked to X-linked mental retardation (XLMR). These authors demonstrate PHF8 to be a histone demethylase with activity against H4K20me1. It has a role in regulating gene expression as well as in neuronal cell survival and craniofacial development in zebrafish. The results suggest there may be a link between histone methylation dynamics and XLMR.
- Página:
503
- Publicación:
Nature
- Volúmen:
466
- Número:
7305
- Periodo:
22 Julio 2010
- ISSN:
00280836
- SrcID:
00280836-2010-07-22.txt
- Documento número 308093
- Actualizado el martes, 23 de mayo de 2017 03:58:20 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:20 p. m.
- Enlace directo
- Artículo:
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
- Autor:
Wen Liu
Bogdan Tanasa
Oksana V. Tyurina
Tian Yuan Zhou
Reto Gassmann
Wei Ting Liu
Kenneth A. Ohgi
Chris Benner
Ivan Garcia-Bassets
Aneel K. Aggarwal
Arshad Desai
Pieter C. Dorrestein
Christopher K. Glass
Michael G. Rosenfeld
- Resumen:
These authors show that the JmjC domain-containing protein PHF8 has histone demethylase activity against H4K20me1 and is linked to two distinct events during cell cycle progression. PHF8 is recruited to the promoters of genes involved in the G1–S phase transition, where it removes H4K20me1 and contributes to gene activation, whereas dissociation of PHF8 from chromatin in prophase allows H4K20me1 to accumulate during mitosis.
- Página:
508
- Publicación:
Nature
- Volúmen:
466
- Número:
7305
- Periodo:
22 Julio 2010
- ISSN:
00280836
- SrcID:
00280836-2010-07-22.txt
- Documento número 308094
- Actualizado el martes, 23 de mayo de 2017 03:58:20 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:20 p. m.
- Enlace directo
- Artículo:
LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium RES Here the authors show that in non-excitable LNCaP prostate cancer cells, the large-conductance, voltage- and calcium-activated potassium (BK) channel can be activated at negative voltages without rises in intracellular Ca2+ concentration, by interacting with an auxiliary protein, the leucine-rich repeat containing protein 26. This auxiliary protein modulates BK channel gating by enhancing the allosteric coupling between voltage-sensor activation and the channel's closed–open transition.
- Autor:
Jiusheng Yan
Richard W. Aldrich
- Página:
513
- Publicación:
Nature
- Volúmen:
466
- Número:
7305
- Periodo:
22 Julio 2010
- ISSN:
00280836
- SrcID:
00280836-2010-07-22.txt
- Documento número 308095
- Actualizado el martes, 23 de mayo de 2017 03:58:20 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:20 p. m.
- Enlace directo