- importsource = "00280836-2010-04-15.txt"
- Artículo:
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
- Autor:
Mark E. Davis
- Resumen:
It has previously been shown in mice and non-human primates that systemically delivered short RNA molecules can inhibit gene expression. Here it is shown that a short interfering RNA (siRNA) can be systemically delivered, using nanoparticles, to a solid tumour in humans. The siRNA mediates cleavage of its target mRNA, thereby also reducing levels of the encoded protein. This proof-of-principle study confirms the potential of this technology for treating human disease
- Página:
1067
- Publicación:
Nature
- Volúmen:
464
- Número:
7291
- Periodo:
15 Abril 2010
- ISSN:
00280836
- SrcID:
00280836-2010-04-15.txt
- Documento número 307372
- Actualizado el martes, 23 de mayo de 2017 03:58:15 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:15 p. m.
- Enlace directo
- Artículo:
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
- Autor:
Rajnish A. Gupta
- Resumen:
Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome. Here it is shown that lincRNAs in the HOX genetic loci are dysregulated during breast cancer progression in human cells, and that expression levels of the lincRNA called HOTAIR can predict whether a tumour will metastasize. Moreover, enforced expression of HOTAIR can lead to altered patterns of binding of the PRC2 protein to the genome
- Página:
1071
- Publicación:
Nature
- Volúmen:
464
- Número:
7291
- Periodo:
15 Abril 2010
- ISSN:
00280836
- SrcID:
00280836-2010-04-15.txt
- Documento número 307373
- Actualizado el martes, 23 de mayo de 2017 03:58:15 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:15 p. m.
- Enlace directo
- Artículo:
Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme
- Autor:
Rafael F. Say
- Resumen:
Thermophilic bacteria and archaea use carbon dioxide or carbon monoxide as a starting material for making the organic substances used in cellular molecules. A central enzyme in this pathway has now been discovered, namely fructose 1,6-bisphosphate aldolase/phosphatase. This enzyme might represent the ancestral gluconeogenic enzyme
- Página:
1077
- Publicación:
Nature
- Volúmen:
464
- Número:
7291
- Periodo:
15 Abril 2010
- ISSN:
00280836
- SrcID:
00280836-2010-04-15.txt
- Documento número 307374
- Actualizado el martes, 23 de mayo de 2017 03:58:15 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:15 p. m.
- Enlace directo
- Artículo:
CpG islands influence chromatin structure via the CpG-binding protein Cfp1
- Autor:
John P. Thomson
- Resumen:
Most human gene promoters are embedded within CpG islands that lack DNA methylation and coincide with sites at which histone H3 lysine 4 is trimethylated (H3K4me3 sites). Here, a zinc-finger protein, Cfp1, is found to be associated with non-methylated CpG islands and H3K4me3 sites throughout the genome in the mouse brain. A primary function of non-methylated CpG islands might be to genetically determine the local chromatin modification state by interaction with Cfp1 and perhaps other CpG-binding proteins
- Página:
1082
- Publicación:
Nature
- Volúmen:
464
- Número:
7291
- Periodo:
15 Abril 2010
- ISSN:
00280836
- SrcID:
00280836-2010-04-15.txt
- Documento número 307375
- Actualizado el martes, 23 de mayo de 2017 03:58:15 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:15 p. m.
- Enlace directo
- Artículo:
Q&A
- Autor:
Virginia Gewin
- Resumen:
Evolutionary geneticist Harmit Malik of the Fred Hutchinson Cancer Research Center in Seattle, Washington, has won the 2010 Vilcek Prize for Creative Promise in Biomedical Science for his work on the coevolution of humans and diseases
- Página:
1089
- Publicación:
Nature
- Volúmen:
464
- Número:
7291
- Periodo:
15 Abril 2010
- ISSN:
00280836
- SrcID:
00280836-2010-04-15.txt
- Documento número 307376
- Actualizado el martes, 23 de mayo de 2017 03:58:15 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:15 p. m.
- Enlace directo
