Catálogo de revistas impresas de la biblioteca

Se encontraron 132 resultados.

Artículo:: Crystal structure of the FTO protein reveals basis for its substrate specificity
Autor:: Zhifu Han
Resumen:: The fat mass and obesity-associated (FTO) gene has been associated with increased body weight. The FTO protein has DNA/RNA demethylase activity. Here, the crystal structure of human FTO in complex with the mononucleotide 3-methylthymidine is presented. The structure provides a basis for understanding the substrate specificity of FTO, and should serve as a foundation for the design of FTO inhibitors
Página:: 1205
Publicación:: Nature
Volúmen:: 464
Número:: 7292
Periodo:: 22 Abril 2010
ISSN:: 00280836
SrcID:: 00280836-2010-04-22.txt

Artículo:: Isolation of the elusive supercomplex that drives cyclic electron flow in photosynthesis
Autor:: Masakazu Iwai
Resumen:: During photosynthesis, light energy is used by photosystems I and II to establish electron flow, which ultimately results in the production of ATP and NADPH. Two modes of electron flow exist, a linear electron flow and a cyclic electron flow (CEF). The latter pathway generates more ATP, but its molecular components have been elusive. Here, a combination of biochemical and spectroscopic techniques has been used to identify the supercomplex that drives CEF in the green alga Chlamydomonas reinhardtii
Página:: 1210
Publicación:: Nature
Volúmen:: 464
Número:: 7292
Periodo:: 22 Abril 2010
ISSN:: 00280836
SrcID:: 00280836-2010-04-22.txt

Artículo:: Ku is a 5?-dRP/AP lyase that excises nucleotide damage near broken ends
Autor:: Steven A. Roberts
Resumen:: Most agents that generate breaks in DNA leave 'dirty ends' that cannot be joined immediately; instead, intervening steps are required to restore the integrity of nucleotides at the break. Here it is shown that the non-homologous end joining pathway requires a 5?-dRP/AP lyase activity to remove abasic sites at double-strand breaks. Surprisingly, this activity is catalysed by the Ku70 protein, which, together with its partner Ku86, had been thought only to recognize broken DNA ends and to recruit other factors that process ends
Página:: 1214
Publicación:: Nature
Volúmen:: 464
Número:: 7292
Periodo:: 22 Abril 2010
ISSN:: 00280836
SrcID:: 00280836-2010-04-22.txt

Artículo:: Super-resolution biomolecular crystallography with low-resolution data
Autor:: Gunnar F. Schröder
Resumen:: X-ray crystallography has become the most common way for structural biologists to obtain the three-dimensional structures of proteins and protein complexes. However, crystals of large macromolecular complexes often diffract only weakly (yielding a resolution worse than 4 Å), so new methods that work at such low resolution are needed. Here a new method is described by which to obtain higher-quality electron density maps and more accurate molecular models of weakly diffracting crystals
Página:: 1218
Publicación:: Nature
Volúmen:: 464
Número:: 7292
Periodo:: 22 Abril 2010
ISSN:: 00280836
SrcID:: 00280836-2010-04-22.txt

Artículo:: RNA interference: Homing in on delivery
Autor:: Monya Baker
Resumen:: The scientific community now seems convinced that small RNAs will become therapies, if new tools can help these large molecules to make it safely into cells. Monya Baker reports
Página:: 1225
Publicación:: Nature
Volúmen:: 464
Número:: 7292
Periodo:: 22 Abril 2010
ISSN:: 00280836
SrcID:: 00280836-2010-04-22.txt

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