- aut = "Zhihua Liu"
- Artículo:
Termination of autophagy and reformation of lysosomes regulated by mTOR
- Autor:
Li Yu
Christina K. McPhee
Lixin Zheng
Gonzalo A. Mardones
Yueguang Rong
Junya Peng
Na Mi
Ying Zhao
Zhihua Liu
Fengyi Wan
Dale W. Hailey
Viola Oorschot
Judith Klumperman
Eric H. Baehrecke & Michael J. Lenardo
- Resumen:
When cells are starved, the enzyme TOR is inhibited, inducing autophagy. In this process, autophagosomes sequester intracellular components and then fuse with lysosomes, producing autolysosomes in which cargo is degraded to regenerate nutrients. Now, a mechanism is revealed by which lysosomes are re-formed. When starvation conditions are prolonged, mTOR is re-activated; this attenuates autophagy and results in tubules and vesicles extruding from the autolysosome and maturing into functional lysosomes.
- Página:
942
- Publicación:
Nature
- Volúmen:
465
- Número:
7300
- Periodo:
17 Junio 2010
- ISSN:
00280836
- SrcID:
00280836-2010-06-17.txt
- Documento número 307827
- Actualizado el martes, 23 de mayo de 2017 03:58:18 p. m.
- Creado el martes, 23 de mayo de 2017 03:58:18 p. m.
- Enlace directo
- Artículo:
Termination of autophagy and reformation of lysosomes regulated by mTOR
- Autor:
Li Yu
Christina K. McPhee
Lixin Zheng
Gonzalo A. Mardones
Yueguang Rong
Junya Peng
Na Mi
Ying Zhao
Zhihua Liu
Fengyi Wan
Dale W. Hailey
Viola Oorschot
Judith Klumperman
Eric H. Baehrecke & Michael J. Lenardo
- Resumen:
When cells are starved, the enzyme TOR is inhibited, inducing autophagy. In this process, autophagosomes sequester intracellular components and then fuse with lysosomes, producing autolysosomes in which cargo is degraded to regenerate nutrients. Now, a mechanism is revealed by which lysosomes are re-formed. When starvation conditions are prolonged, mTOR is re-activated; this attenuates autophagy and results in tubules and vesicles extruding from the autolysosome and maturing into functional lysosomes.
- Página:
942
- Publicación:
Nature
- Volúmen:
465
- Número:
7300
- Periodo:
17 Junio 2010
- ISSN:
00280836
- SrcID:
00280836-2010-06-17.txt
- Documento número 1206696
- Actualizado el martes, 10 de julio de 2018 11:33:59 a. m.
- Creado el martes, 10 de julio de 2018 11:33:59 a. m.
- Enlace directo
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