- Artículo:
LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium RES Here the authors show that in non-excitable LNCaP prostate cancer cells, the large-conductance, voltage- and calcium-activated potassium (BK) channel can be activated at negative voltages without rises in intracellular Ca2+ concentration, by interacting with an auxiliary protein, the leucine-rich repeat containing protein 26. This auxiliary protein modulates BK channel gating by enhancing the allosteric coupling between voltage-sensor activation and the channel's closed–open transition.
- Autor:
Jiusheng Yan
Richard W. Aldrich
- Página:
513
- Publicación:
Nature
- Volúmen:
466
- Número:
7305
- Periodo:
22 Julio 2010
- ISSN:
00280836
- SrcID:
00280836-2010-07-22.txt
- Documento número 1206964
- Actualizado el martes, 10 de julio de 2018 11:34:01 a. m.
- Creado el martes, 10 de julio de 2018 11:34:01 a. m.
- Enlace directo