Many large mammals became extinct worldwide at the end of the Pleistocene epoch, around 12,000 years ago. Here, it is shown that smaller mammals, which often provide much more comprehensive fossil records than large mammals, were much less likely to respond to the Pleistocene–Holocene transition by becoming extinct. Instead, diversity and evenness suffered, so that less abundant species became rarer, with more generalist 'weedy' species becoming more common.