A practical method of progressive collapse analysis of reinforced concrete flat-plate buildings using yield-line method is suggested. Methods for calculation of punching shear and evaluation of inelastic deformations are proposed and illustrated using a building example. The outlined procedure allows the designer to evaluate the resistance of flat-plate structures to progressive collapse, using tools already available in most design offices. The proposed method also allows the designer to clearly identify places where additional reinforcing will effectively increase building robustness, thereby reducing the total use of material and labor in field.