Two controversial studies that showed how to make the H5N1 avian influenza virus transmissible among mammals have left scientists wondering which kinds of studies are worth the risk and how potentially dangerous results should be reviewed and safely communicated to the public and public health experts.

This week's Newsmakers are Alan Alda and Jane Lubchenco. Alda talks with Science about the second Flame Challenge: What is time and how would you explain it to an 11-year-old? Lubchenco, the head of the U.S. National Oceanic and Atmospheric Administration, has announced her resignation.

The National Ignition Facility faces an uncertain future after its managers admitted to Congress this month that they need at least another 3 years to try to identify what has prevented the giant laser fusion lab in California from achieving ignition.